Russell Wilson threw four touchdown passes, two to Tyler Lockett, as the Seattle Seahawks opened their season with a 28-16 victory against the host Indianapolis Colts on Sunday.

Wilson quickly took to new offensive coordinator Shane Waldron's system, putting up a perfect passer rating of 158.3 in the opening half when he completed 9 of 11 passes for 166 yards and three TDs in guiding Seattle to a 21-10 lead.

Tight end Gerald Everett scored on a 9-yard catch and wideout DK Metcalf on a 15-yarder for Seattle. The latter, with 6:45 remaining, gave Seattle a 28-10 advantage.

Wilson finished 18 of 23 for 254 yards.

The Seahawks spoiled the Indianapolis debut of quarterback Carson Wentz, acquired by the Colts in an offseason trade with Philadelphia for a pair of draft picks. Wentz, who missed most of training camp because of foot surgery and spent another week in quarantine after close contact with a staff member who tested positive for COVID-19, was 25 of 38 for 251 yards and two touchdowns, both to Zach Pascal.

Seattle's defense limited Jonathan Taylor, the NFL's third-leading rusher last season, to 56 yards on 17 carries. Taylor also had six receptions for 60 yards.

The Seahawks made good use of their running game, with Chris Carson gaining a game-high 91 yards on 16 attempts.

Lockett, who had four receptions for game-high 100 yards, made an over-the-shoulder catch in the back of the end zone for a 23-yard touchdown on Seattle's first possession. He beat the secondary straight down the field for a 69-yard score with 41 seconds remaining in the first half to make the score 21-10.

Wilson hit Everett on a crossing route for a touchdown on the Seahawks' second possession, giving them a 14-3 lead with 11:22 left in the half.

The Colts responded with a touchdown drive capped by Wentz's 10-yard pass to Pascal.

Those two also connected on an 11-yarder with 2:08 remaining to complete the scoring.

Indianapolis' Rodrigo Blankenship kicked a 21-yard field goal on the game's opening drive.

--Field Level Media