ORCHARD PARK, N.Y. -- Eli Manning passed for 212 yards and three touchdowns Sunday as the New York Giants beat the Buffalo Bills 24-10 at Ralph Wilson Stadium.

Receivers Dwayne Harris and Ruben Randle and running back Rashad Jennings caught touchdowns for the Giants (2-2), who have won two in a row.

The Giants defense stifled the Bills offense throughout the first half and made a crucial goal line stand early in the fourth quarter in holding Buffalo to its lowest point total of the season. The Bills continued to show a lack of discipline with 16 penalties for a total of 46 this season.

Bills quarterback Tyrod Taylor passed for 274 yards and a touchdown. Rookie running back Karlos Williams scored a touchdown for the fourth straight game, but was held to 40 yards rushing.

Buffalo (2-2) was penalized 16 times for 125 yards, including twice on plays that appeared to be touchdowns.

The Giants put the game out of reach with 7:42 remaining when Jennings took a short pass and shrugged off three tacklers on his way to a 51-yard touchdown that made it 24-10 after running back Andre Williams' 2-point conversion run.

Giants cornerback Prince Amukamara stripped the ball from Bills receiver Robert Woods at the Giants' 40 on Buffalo's ensuing drive.

Manning was intercepted for the first time this season at the goal line by Bills cornerback Stephon Gilmore with 3:51 remaining. But the Bills were unable to convert the turnover into points.

The Bills got within a touchdown with just under 10 minutes to play when Taylor lofted a 23-yard touchdown pass to Williams wheeling out of the backfield.

After struggling to move the ball on its first eight series, the Bills put together two sustained drives in the second half that resulted in no points.

Buffalo's 78-yard drive in the third quarter doubled its offensive output to that point in the game, but ended with Dan Carpenter missing a 30-yard field goal wide left. Taylor appeared to score on a 26-yard scramble earlier in the drive, but the play was nullified by a holding penalty on left guard Kraig Urbik.

Buffalo gained 66 yards on its next drive but stalled out on a fourth-and-goal play at the Giants' 1-yard line. On fourth-and-goal, Taylor completed a pass to Williams in the flat, but New York defenders Dominique Rodgers-Cromartie and J.T. Thomas III stopped Williams for a loss.

Manning threw for touchdowns on consecutive drives as the Giants built a 16-3 halftime lead.

Randle's 11-yard touchdown reception early in the second quarter capped a 76-yard scoring drive on which the Bills took three defensive penalties, including one on a Giants' field goal attempt.

Linebacker Devon Kennard's interception at the Buffalo 32 led to Manning's 21-yard touchdown pass to Harris two plays later. Kicker Josh Brown missed the extra point try, leaving the score at 9-3.

The teams traded field goals early on. Brown kicked a 47-yarder on the Giants' opening drive, and Carpenter made one from 51 yards out to tie the game at 3-3.

NOTES: Giants WR Odell Beckham Jr. caught five passes for 38 yards and set an NFL record with 1,612 receiving yards through his first 16 games. The previous record of 1,593 yards was set by Houston's Bill Groman in 1961. … The Bills were without starting RB LeSean McCoy (hamstring) and top WR Sammy Watkins (groin). ... Bills safety Bacarri Rambo (quadriceps) and Giants cornerback Jayron Hosley (possible concussion) left the game and did not return. … DE Owa Odighizauwa, the Giants' third-round draft pick, made his season debut after missing three games with a foot injury.