Eighth-seeded Loyola-Chicago took a large step toward its second Final Four in four years with a 71-58 victory over top-seeded Illinois in a Midwest Region second-round game on Sunday afternoon in Indianapolis.

Not only did the Ramblers knock out their in-state rival, they did not let the nation's No. 2 team hold a lead as the country's best scoring defense stifled the Illini from start to finish. Illinois did not get closer than five points in the final 33 minutes as Loyola swiped the ball 12 times and forced 17 turnovers for the game.

Third-team All-American senior center Cameron Krutwig paced Loyola (26-4) with 19 points, 12 rebounds, five assists and three steals. Lucas Williamson, the other holdover from Loyola's 2018 Final Four team, added 14 points and two blocks while Marquise Kennedy contributed 14 points off the bench.

The Ramblers, who have won 19 of their last 20 games, will meet 12th-seeded Oregon State (18-12) in the Sweet 16 after the Beavers defeated fourth-seeded Oklahoma State 80-70 on Sunday.

Illinois (24-7), which entered the day with 15 wins in its last 16 games, shot just 44.9 percent from the floor and scored a season-low in points. The Illini failed to earn their first Sweet 16 berth since 2005.

Second-team All-American center Kofi Cockburn posted 21 points and nine rebounds, Adam Miller scored 10 points and Andre Curbelo contributed nine points and seven assists, but first-team All-American guard Ayo Dosunmu was limited to nine points on 4-of-10 shooting while committing six turnovers. Loyola snapped his streak of 42 consecutive games in double figures.

Given the opportunity to play the state's flagship school for the first time in 10 years, Loyola seized the chance from the start.

Krutwig flipped a 10-footer over Cockburn on Loyola's first possession, then ran a give-and-go with Keith Clemons for an alley-oop layup the next time down the floor to give the Ramblers the lead for good.

Loyola's aggressive defense thwarted Illinois all game with a variety of looks out of its trademark man-to-man. The Ramblers switched and double-teamed all over the floor in order to force the ball out of the hands of Dosunmu and Cockburn.

Cockburn didn't earn his first basket until he dunked at the 8:55 mark of the first half, which pulled Illinois within 19-11.

The Ramblers' perpetual lead swelled to 33-19 on Clemons' 3-pointer with 1:17 to go, but Illinois headed into the locker room with momentum as Curbelo fed Cockburn for a dunk that became a 3-point play - then Curbelo floated a pass to Cockburn for an alley-oop jam in the waning seconds to cut the margin to 33-24 at the break.

Illinois pulled within six points on multiple occasions early in the second half, but Loyola responded every time. Down the stretch, Krutwig twice swiped the ball out of Dosunmu's hands as the help guy on the double team.

--Field Level Media