Trey Mancini drove in three runs, two of which came on a tiebreaking single in the seventh inning, and the visiting Baltimore Orioles defeated the Boston Red Sox 10-3 in the second game of a day-night doubleheader.

Boston (107-52) handed the Orioles (46-112) their worst loss of the season in a 19-3 rout in Game 1.

In the nightcap, Red Sox starter Chris Sale went 4 2/3 innings and gave up three runs on four hits and a walk while striking out eight. He is trying to get ready for the playoffs after being placed on the disabled list twice due to shoulder inflammation issues.

For the Orioles, who went with the pitching-by-committee approach again due to their depleted rotation, Jimmy Yacabonis got the start. The right-hander gave up two runs on four hits in 3 1/3 innings with four walks and two strikeouts.

Tanner Scott (3-2) earned the victory with 2 2/3 innings of relief, giving up one run and striking out three. Paul Fry got his second save after going the final three innings and retiring all nine batters he faced.

The Orioles took a 2-0 lead in the first inning. Sale hit Cedric Mullins with a pitch to start the game, and Mancini tripled him in with one out.

Two batters later, Renato Nunez hit a sacrifice fly for Baltimore's second run as Sale needed 23 pitches to get through the inning.

The Red Sox got one back in the bottom of the inning thanks to Orioles shortstop Jonathan Villar's error as Yacabonis struggled through a 35-pitch frame.

Boston tied it in the fourth when Tzu-Wei Lin lined an RBI triple to right off Yacabonis with one out. The Orioles took a 3-2 lead on an Adam Jones RBI double in the fifth, but the Red Sox tied it in the bottom half on Blake Swihart's run-scoring single.

The Orioles had runners on second and third with one out in the seventh when Mancini singled to center off Matt Barnes (6-4) and drove both in for a 5-3 lead.

Nunez added an RBI single later in the inning to give Baltimore a 6-3 advantage.

The Orioles scored four more in the ninth, one on a Craig Kimbrel wild pitch, two on a John Andreoli double and one thanks to Steve Wilkerson's single.

--Field Level Media