PHILADELPHIA -- Justin Masterson pitched six strong innings and shortstop Xander Bogaerts keyed a six-run third inning with a three-run triple as the Boston Red Sox beat the Philadelphia Phillies 6-2 on Thursday night.

Masterson, making his first start of the season after posting a career-worst 5.88 ERA with Cleveland and St. Louis in 2014, allowed two runs and three hits. He struck out seven and walked one.

At the plate, Masterson had the first two-hit game of his career. He drove in a run with the first of those, a single in the third inning.

Craig Breslow, Tommy Layne and Edward Mujica each pitched a scoreless inning in relief for Boston.

Philadelphia starter David Buchanan took the loss. He is winless in his last 10 starts, dating to a victory over Houston last Aug. 6. He went three innings and yielded six runs and seven hits while striking out one and walking four.

Buchanan retired the first two batters he faced in the third inning, but first baseman David Ortiz and left fielder Hanley Ramirez both singled, the latter off Buchanan's glove. The pitcher recovered the ball behind the mound but threw it into the stands attempting to retire Ramirez at first, allowing the runners to advance to second and third.

Third baseman Pablo Sandoval walked to load the bases and right fielder Shane Victorino legged out a grounder to deep third for an RBI single. A walk to catcher Ryan Hanigan forced in another run before Bogaerts blooped a triple to right, clearing the bases and making it 5-0.

Masterson chased in the inning's sixth run with a single up the middle.

The Phillies answered with two runs in the bottom of the third on Masterson's wild pitch and a single by second baseman Chase Utley.

NOTES: Boston RHP Koji Uehara (left hamstring strain) will make a rehab appearance Saturday for Class A Greenville. He could be activated before Monday's home opener against the Washington Nationals. ... Phillies manager Ryne Sandberg feigned ignorance when asked about the comments of closer Jonathan Papelbon. "The Red Sox are a part of who I am, man," Papelbon, once a member of the Red Sox, told the Boston Globe. "I don't really feel much like a Phillie." Sandberg's response before Thursday's game: "All I know is, he's been a good influence here." ... Phillies RHP Chad Billingsley (right flexor tendon surgery) is scheduled to make a four-inning rehab start Friday at Triple-A Lehigh Valley. ... Philadelphia OF Domonic Brown (left Achilles tendinitis) began a rehab assignment at Class A Clearwater on Thursday. ... The Phillies announced that RHP Sean O'Sullivan, currently at Lehigh Valley, will start Sunday's game against Washington. A corresponding roster move will be made.