BALTIMORE -- After Baltimore blew a ninth-inning lead and then fell behind in the 10th against the Boston Red Sox, the Orioles rallied for a dramatic 5-4 victory on a homer by left fielder David Lough on Saturday night.

Baltimore snapped a five-game losing streak. The Red Sox have lost five of eight games after starting the season 7-3.

Boston's Xander Bogaerts led off the 10th with a home run against Baltimore right-hander Brad Brach (1-1) that gave the Red Sox a 4-3 lead. But Orioles center fielder Adam Jones started the bottom half of the inning with a triple off Koji Uehara (1-1) and first baseman Chris Davis tied the score on a sacrifice fly before Lough's towering shot to right won it.

Baltimore's Jimmy Paredes had a career-high four hits, including his third home run of the season

The game was a rematch between Boston right-hander Justin Masterson and Orioles lefty Wei-Yin Chen, who met for the second time in less than a week. In the first meeting, Masterson got the best of Chen in the Red Sox's 7-1 victory.

This time, both pitchers were effective.

Chen (1-1) tied a career high by pitching eight innings, and he retired the final 12 batters he faced. He allowed two runs and four hits with five strikeouts and one walk.

Masterson (2-1) was also solid, giving up three runs and seven hits with three strikeouts and one walk in seven innings.

Red Sox first baseman Mike Napoli hit his first home run since Sept. 1, spanning a span of 87 at-bats.

The Orioles opened a 2-0 lead when left fielder Alejandro De Aza and Paredes hit back-to-back doubles in the first inning. Davis later followed with a sacrifice fly.

The Red Sox tied the score in the second on a two-run homer by Napoli that hit the right-field foul pole.

A two-out single for right fielder Allen Craig in fourth nearly gave Boston the lead, but De Aza easily threw out left fielder Hanley Ramirez trying to score from second.

Paredes then came up big again with a towering solo home run to right center in the fifth.

Hundreds of protesters, outraged over the death of a 25-year-old man who died after being arrested by Baltimore police, gathered outside Camden Yards and smashed car windows, damaged store fronts and threw objects at law enforcement officials. Police helicopters hovered above the stadium throughout the game.

NOTES: Orioles manager Buck Showalter missed the beginning of the game to attend the funeral of his father-in-law in Nashville, Tenn., but was back in the dugout by the third inning. ... Boston recalled RHP Matt Barnes from Triple-A Pawtucket after RF Shane Victorino (right hamstring injury) was placed on the 15-day DL. ... Orioles C Matt Wieters (right elbow tendinitis) is expected to catch as many as five innings in an extended spring training game Monday. ... After starting seven of the past 10 games, Red Sox INF Brock Holt was held out of the lineup despite batting .424.