White Sox 3, Indians 2: Alex Rios clubbed a two-run homer and host Chicago won the final game of the rain-shortened series.

Rios ended an 0-for-13 skid by hitting an 0-2 fastball into the bullpen in left off Cleveland starter Zach McAllister for a 3-0 lead in the fifth. Jeff Keppinger added two hits and an RBI in support of White Sox starter Jose Quintana (2-0), who allowed two runs and four hits in five innings.

Michael Brantley had two hits for the Indians and McAllister (1-3) worked 5 2/3 innings, allowing three runs, five hits and five walks.

Quintana retired the first nine batters he faced and escaped a bases-loaded one-out jam in the fifth. After the first three batters reached base in the sixth, Quintana gave way to reliever Nate Jones, who allowed a sacrifice fly to Mark Reynolds to cut the deficit to 3-2 but struck out Nick Swisher and got Ryan Raburn to fly out.

The White Sox scored a run in the first after Alejandro De Aza led off with a walk, stole second and came home on a single to center by Keppinger. They tacked on two more runs in the fifth when Keppinger singled with two outs and Rios went deep on an up-and-in fastball for his sixth homer of the season.

GAME NOTEBOOK: Indians catcher and leading hitter Carlos Santana sat out with the flu. … Cleveland SS Asdrubal Cabrera did not play because of a right quad injury that occurred following his two-run single in the eighth inning of Monday’s series opener that gave the Indians a 3-2 lead they would not lose. Cabrera, who is hitting .156, is day-to-day. … The White Sox entered the game with the major league’s second-lowest average with runners in scoring position (.163) and went 1-for-8 in the series finale.