Eli Manning found Victor Cruz from 28 yards out with 8:15 remaining in the fourth quarter as the New York Giants rallied to post a 29-16 road victory over Philadelphia on Sunday and end their six-game losing streak to the Eagles.

Cruz outmuscled two defenders for the ball at the Eagles 1 and got it over the goal line for his second touchdown of the game.

Michael Vick, who started for the Eagles after suffering a concussion last week against Atlanta, was knocked out of the game in the fourth quarter with a broken hand.

Vick completed 16 of 23 passes for 176 yards and one interception. He went to the locker room late in the third for X-rays, which revealed the break, but returned for one series in the fourth before giving way to Mike Kafka.

Kafka's first pass attempt was picked off by Aaron Ross, who also intercepted Vick earlier in the game. The Eagles also lost receiver Jeremy Maclin to a hamstring injury.

Philadelphia (1-2) trailed 14-0 after one quarter but cut the deficit to one point by halftime. Alex Henery got the Eagles on the board with a 21-yard field goal and, after LeSean McCoy scored on an 11-yard run with two minutes remaining, booted a 38-yarder as time expired.

McCoy gained 128 yards on 21 carries.

Manning connected with Brandon Jacobs on a 40-yard scoring play 8:48 into the game to give New York (2-1) the lead. With 62 seconds left in the first, Cruz hauled in a pass from Manning, broke one tackle and sprinted 74 yards down the field for his first career touchdown after Kent Coleman and Nnamdi Asomugha collided.

Like Vick, Manning also was 16 of 23, but for 254 yards and a career high-tying four TDs.