Dario Saric added 19 points with four 3s, and Joel Embiid poured in 18 points.
The 76ers shot 16-for-33 on 3-pointers. Philadelphia didn't have a 3-point basket in the last seven minutes, having done enough long-range damage by then.
Ben Simmons tacked on 16 points on 8-for-9 shooting from the field, and JJ Redick provided 14 points. Marco Belinelli and Ersan Ilyasova each had 11 points off the bench for Philadelphia.
Dwight Howard scored 30 points for the Hornets, hitting 12 of 17 shots from the field.
Nic Batum's 12 points and Marvin Williams' 11 points weren't enough, as the four starters other than Howard combined for 33 points.
Treveon Graham added 12 points, Frank Kaminsky had 11 and Jeremy Lamb supplied 10 points for the Hornets, who have lost four in a row following a five-game winning streak.
Hornets guard Kemba Walker, the team's leading scorer, was 1-for-9 from the field, including 0-for-5 on 3-pointers. His field goal came with about 7 1/2 minutes remaining, pulling the Hornets to within 110-100.
Howard, who made a buzzer 3-pointer to end the first half, scored the first five points of the second half to help the Hornets recover from what had been a largely ragged second quarter.
The 76ers, who lost three of their previous five games, finished the first half on a 21-11 spurt for a 71-59 lead.
Philadelphia shot 67.5 percent from the field in the first half, an offensive outburst that might have been bigger if not for nine turnovers. The 76ers had only five second-half giveaways.
Redick was 3-for-4 on 3-pointers in the first half.
The 76ers' most-recent victory also came against Charlotte, winning 110-99 last week at home.
Charlotte had 28 first-half points from its reserves, accounting for nearly half of the points production.
This was Philadelphia's second game of a four-game road stretch.
--Field Level Media
Philadelphia | Charlotte | |
Robert Covington 22 | Scoring | Dwight Howard 30 |
Ben Simmons 13 | Assists | Nicolas Batum 10 |
Ben Simmons 8 | Rebounds | Dwight Howard 6 |
Robert Covington 3 | Free Throws Made | Dwight Howard 5 |
Robert Covington 2 | Steals | Jeremy Lamb 2 |
Robert Covington 2 | Blocks | Dwight Howard 3 |
Team | Points | FG% | 3PM-3PA | FTM-FTA | Assists | Rebounds | Blocks | Steals | Turnovers |
Philadelphia | 128 | 57.5 | 16-33 | 12-15 | 35 | 44 | 4 | 6 | 14 |
Charlotte | 114 | 50.0 | 11-29 | 23-31 | 26 | 33 | 5 | 7 | 10 |