SAN FRANCISCO -- University of San Francisco product Bradley Zimmer estimates he has seen 100 games at AT&T Park in his lifetime.

Until Monday night, the Cleveland Indians center fielder was never a central figure in any of those contests.

The Indians took advantage of two throwing errors on seemingly routine plays at first base to rally for a 5-3 victory over the San Francisco Giants in the opener of a three-game interleague series.

Right-hander Josh Tomlin combined with two relievers on a six-hitter, and Yan Gomes belted a home run, helping Cleveland snap a season-worst four-game losing streak.

"It's good to get back to playing our style of baseball," Tomlin said after the Indians bounced back following three consecutive losses at Oakland. "We took advantage of (the Giants') mistakes. That's kind what we've done in the past."

The loss in the opener of a 10-game homestand was the Giants' 14th in their past 18 home games.

"It's always tough to lose," San Francisco manager Bruce Bochy said. "You hate to shoot yourself in the foot, which we did."

The Indians trailed 3-1 with two outs in the fifth inning and Giovanny Urshela on second base when Giants pitcher Matt Moore knocked down Zimmer's one-hopper back to the mound.

Moore recovered the ball quickly, took a couple of steps toward first base and underhanded a toss that sailed well over the head of first baseman Jae-Gyun Hwang, allowing Urshela to jog home.

"Maybe he saw me running," said Zimmer, who admitted he was disappointed to see Moore get a glove on a potential run-scoring hit. "Anytime I put the ball in play, I bust my butt. That's just baseball."

With the inning having been extended, Francisco Lindor blooped a broken-bat single to center field, scoring Zimmer with the tying run.

"Sometimes when you hustle," Indians manager Terry Francona said of Zimmer's dash to first base, "if he doesn't run hard, maybe that (the errant toss) doesn't happen."

After Jose Ramirez doubled to open the Cleveland sixth, Brandon Guyer bunted to Hwang, who threw errantly to first base. Ramirez scored the go-ahead run from second when the ball got past second baseman Joe Panik, who was covering first on the play.

Moore took the blame for the defeat.

"That ended up being what cost us the game," he said of his mishap. "It's something that's hard to shake off."

It wasn't the brand of ball Zimmer grew accustomed to seeing from the Giants, who won the first of their three recent titles while he was in college across town.

"It seems like they're not having their best year," said Zimmer, who finished 0-for-5.

The Indians added an insurance run in the ninth on Lindor's third hit of the game, a two-out single that plated Urshela for a 5-3 lead.

Tomlin (6-9) allowed three runs and six hits in 7 1/3 innings for his second consecutive win. Left-hander Andrew Miller got the final two outs of the eighth inning before closer Cody Allen pitched a 1-2-3 ninth for his 17th save.

Tomlin struck out five and did not walk a batter. He was pulled despite having thrown only 79 pitches.

"I'm never disappointed to see Miller out there," he said. "It's not about me. It's all about getting a win."

Moore (3-10) lost his second consecutive start. He allowed six hits and four runs, only two of which were earned, in seven innings. He walked one and struck out five.

The Giants finished with two errors after having committed just three in their previous 12 games.

Urshela had two hits and scored twice, and Lindor drove in two runs for the Indians, who won for just the fourth time in 15 interleague games this season and just the second time in eight contests at National League parks.

Gorkys Hernandez had two hits for the Giants, who had won six straight against the Indians.

The Giants fell to 3-8 in interleague games and 11-20 against American League competition since the start of the 2016 season.

Before his throwing error contributed to the Indians' scoring, Moore gave the Giants an early lead with an RBI single in a two-run third inning.

The hit followed a successful replay review by the Giants. Panik initially was called out at home plate while trying to score on a double by Hernandez, but the ruling was overturned.

Hernandez took third on the throw, from where he scored on Moore's hit, giving the Giants a 2-1 lead.

Brandon Crawford hit an RBI double in the fourth inning to increase San Francisco's advantage to 3-1.

Gomes' homer, his sixth of the season, opened the game's scoring in the top of the third.

NOTES: The announced attendance at AT&T Park was 39,538, snapping the Giants' streak of 530 consecutive home sellouts. The streak, which dated back to 2010, was the longest in National League history and second-longest ever in the majors behind a 794-game run at Fenway Park by the Boston Red Sox. ... The AT&T Park attendance was nonetheless the biggest in the majors on Monday night. ... Indians C Yan Gomes is the son-in-law of former Giants All-Star LHP Atlee Hammaker. ... The Giants were without their regular first baseman, Brandon Belt, who missed his second consecutive game with a sprained left wrist. ... Giants 3B Eduardo Nunez went 0-for-4, failing to reach base for the first time in his past 34 games. It had been the longest active streak in the majors. ... After the game, the Giants reinstated 3B Ryder Jones (bruised right wrist) from the 10-day disabled list and sent him to Triple-A Sacramento.