Major league home-run leader Jose Bautista went deep twice, capped by a towering grand slam, as the Toronto Blue Jays slugged their way to a 13-2 throttling of the Minnesota Twins on Thursday night.

With Toronto already leading comfortably in the seventh inning, Bautista sent a Pat Neshek offering deep over the left-field wall for his 53rd home run of the season. No. 54, a solo shot in the ninth inning, gave Bautista a share of the highest single-season home-run total since Ryan Howard belted 58 home runs in 2006.

Bautista finished with three hits and three runs scored while running his RBI total for the season to 124, second in the majors to Miguel Cabrera. The 29-year-old has 30 homers and 68 RBIs in 70 games since the All-Star break.

Edwin Encarnacion also homered twice for the Jays while Travis Snider and Jose Molina chipped in with homers. The six long balls gives Toronto 253 for the season, the fourth-highest total in major-league history.

Casey Janssen (5-2) picked up the win in relief of starter Shawn Hill, who allowed a run on three hits but was pulled after just 4 2/3 innings, having thrown 93 pitches. Hill finishes the year 1-2 with a 2.61 ERA in four starts since returning from ligament replacement surgery.

Francisco Liriano (14-10) earned his third straight loss, allowing five runs on six hits over 5 1/3 innings.

Michael Cuddyer and Drew Butera had run-scoring hits for the Twins, who have lost six of seven.