CINCINNATI -- Carlos Santana hit a pair of two-run homers and Josh Tomlin remained undefeated on the season as the Cleveland Indians defeated the Cincinnati Reds 7-2 in the finale of a four-game home-and-home interleague series Thursday night at Great American Ball Park.

Cleveland (21-17) swept their interstate rivals in a season series for the first time.

Joey Votto hit a two-run homer for Cincinnati (15-26) which has lost four of the past five games played against the Indians at Great American Ball Park.

It didn't help that the Reds lost starting pitcher Tim Adleman in the fourth inning Thursday with a strained left oblique, meaning their struggling bullpen had to log more than five innings.

Rajai Davis had RBI doubles in consecutive at-bats and was 9-for-16 with three doubles, two homers and nine RBIs in the four games, earning Ohio Cup most outstanding player honors.

Tomlin (6-0) gave up two runs and five hits with a walk and seven strikeouts in 7 2/3 innings.

Caleb Cotham (0-3) took the loss in relief of Adleman for Cincinnati. Keyvius Sampson did his best to keep the Indians' offense at bay with one run allowed in three frames, the longest relief stint of his career.

Adleman allowed a hit and a walk through three innings. In the fourth, Francisco Lindor reached on an infield single, and Santana crushed a 1-0 pitch an estimated 414 feet to right-center for his sixth home run, putting Cleveland ahead 2-0.

Three batters later, Adleman exited after being visited on the mound by the training staff, leaving the game in the hands of the Reds' bullpen which had a 6.43 ERA coming in.

Votto tied the score 2-2 with a two-run homer off Tomlin in the fourth. It was Votto's sixth homer of the season.

The Indians got those runs back in the fifth on Davis' RBI double and an RBI single by Lindor, making the score 4-2.

On the next pitch he saw after homering in the fourth, Santana went deep again, this time off Cotham to make it 6-2. It was Santana's sixth career multi-homer run game, his first since 2014.

NOTES: Cleveland outscored Cincinnati 43-16 in the series. ... Reds RHP Homer Bailey threw from 140 feet on Thursday. Bailey's rehab from elbow surgery had been paused due to soreness. ... The Indians began the day three games over .500 for the first time since the end of the 2014 season. ... CF Rajai Davis is, according to Elias, the first Cleveland player since Hal Trosky in 1936 to score nine runs in a three-game stretch. Davis reached base 12 times in those three games.