Detroit defenseman Niklas Kronwall recorded his 400th career point with a first-period goal and rookie defenseman Joe Hicketts notched the first two points of his career with two assists. Frans Nielsen scored the go-ahead goal.
Dylan Larkin added two assists and Jimmy Howard stopped 22 shots for the Red Wings, who were eliminated from playoff contention last week.
Sidney Crosby and Kris Letang scored for the Penguins, while Matt Murray made 21 saves.
Crosby scored 38 seconds into the game. Jake Guentzel made a steal in his own zone, skated along the left side and slid a pass to a wide-open Crosby. He one-timed it past Howard for his 27th goal.
Kronwall tied it with 3:17 remaining in the period. Helm fed him the puck from behind the net and Kronwall ripped a shot from the slot past Murray.
Pittsburgh had an apparent goal disallowed on an officials' review midway through the second period when referees determined the puck didn't cross the goal line. Detroit then scored twice in short order to take a 3-1 lead.
The first of those tallies came on a power play with Jamie Oleksiak in the penalty box for high sticking. Martin Frk passed the puck through traffic to Nielsen, who lifted a shot from the left circle over Murray's right shoulder.
Just 41 seconds later, Glendening scored his first goal of the night when he tipped a Nick Jensen shot from the point through Murray's legs.
The Wings made it 4-1 with 13:39 remaining in the third when Larkin whipped a pass from behind the net to Helm, who scored his 10th goal.
Letang scored his seventh goal this season with 3:16 left. Glendening's 11th goal of the season with the Penguins' net empty clinched Detroit's win.
Pittsburgh won the first two meetings by identical 4-1 scores.
--Field Level Media
Pittsburgh | Detroit | |
Sidney Crosby 1 | Points | Darren Helm 3 |
Sidney Crosby 1 | Goals | Luke Glendening 2 |
Jake Guentzel 1 | Assists | Darren Helm 2 |
N/A | Power Play Goals | Frans Nielsen 1 |
N/A | Short Handed Goals | N/A |
Matt Murray .840 | Save Percentage | Jimmy Howard .917 |
Matt Murray 21 | Saves | Jimmy Howard 22 |
Team | Shots | Goals | Power Play | Penalty Kill | Penalty Mins | Face Offs Won |
Pittsburgh | 24 | 2 | 0-2 | 1-2 | 4 | 31 |
Detroit | 26 | 5 | 1-2 | 2-2 | 4 | 27 |