Red Sox 8, Yankees 5: David Ortiz hit his 450th career homer and Dustin Pedroia went 3-for-3 with three RBIs as visiting Boston took the rubber match of a three-game set from rival New York.

Stephen Drew added an RBI and Brock Holt scored twice for the Red Sox, who managed more than three runs for just the third time in the last 15 games. John Lackey (9-5) allowed five runs (four earned) but stuck around long enough to get the win in five innings, and three relievers bridged the gap to Koji Uehara, who worked a perfect ninth for his 18th save.

Chase Whitley (3-2) suffered the brunt of the punishment for the Yankees, allowing five runs on eight hits and two walks in four-plus innings. Mark Teixeira and Carlos Beltran homered and Derek Jeter recorded two hits and an RBI as New York lost for the sixth time in eight games.

Boston pushed across a run in the second inning and made it a four-run gap in the third when Ortiz came up with two on and took a fastball out to right-center for his 19th home run of this season to move into 37th on the all-time list. The Yankees broke through with a run in the bottom of the frame and cut the deficit to 4-3 when Teixeira and Beltran sandwiched solo home runs around Brian McCann’s groundout.

Whitley walked the leadoff batter in the fifth before being replaced and Shawn Kelley walked the next two before Pedroia’s two-run single highlighted a three-run rally. New York fought back again with two runs in the bottom of the frame but the Red Sox bullpen held from there, and Pedroia tacked on a sacrifice fly in the sixth.

GAME NOTEBOOK: Boston top prospect Mookie Betts made his major-league debut and went 1-for-3 with a run scored. The 21-year-old played a single into a triple in right field that led to a run in the fifth but was otherwise solid with the glove after playing only two minor-league games in right. … Red Sox 3B Xander Bogaerts, who is 6-for-66 in his last 18 games, got the night off as Holt moved to third. … New York hosts Tampa Bay in the opener of a three-game series on Monday while the Red Sox head home to take on the Chicago Cubs.