Colts 27, Jaguars 10: Rookie Andrew Luck ran for a pair of touchdowns and cornerback Darius Butler returned an interception for a score as visiting Indianapolis extended its winning streak to four games.

Luck completed 18 of 26 passes for 227 yards with one interception and Reggie Wayne had eight receptions for 96 yards for the Colts (6-3), who ended their three-game skid against the Jaguars.

With Indianapolis already ahead 3-0 early in the second quarter, Luck rolled to his right on second and goal and ran into the end zone from five yards out after failing to find an open receiver. The young star gave the Colts a 17-0 lead with 7:39 remaining in the first half, scoring on a sneak from the Jaguars 1 on fourth-and-goal.

Butler picked off a pass by Blaine Gabbert and returned it 11 yards for a score with 10:50 left in the third, giving Indianapolis complete control.

Gabbert was 18-of-31 for 209 yards for Jacksonville (1-8) before leaving with a shoulder injury. Chad Henne came in and completed 10 of 16 passes for 121 yards and a scoring toss to Cecil Shorts as the Jaguars dropped their sixth straight game and fell to 0-5 at home.

GAME NOTEBOOK: The Colts suffered a scare in the fourth quarter when Jacksonville S Dawan Landry delivered a hard shoulder tackle to Luck's head. The rookie shook it off and remained in the game. ... Butler also recovered a fumble by Jaguars WR Laurent Robinson in the second quarter, leading to Luck's second touchdown run. ... Jacksonville K Josh Scobee missed a 44-yard field-goal attempt in the first quarter, ending his run of 20 consecutive successful kicks. Scobee fell one shy of setting a franchise record.