ANAHEIM, Calif. -- Franklin Gutierrez's RBI single in the top of the 10th inning snapped a 2-2 tie and propelled the Seattle Mariners to a 5-2 win over the Los Angeles Angels on Friday night at Angel Stadium.

The victory was the Mariners' third in a row and sixth in their last eight games coming off a five-game losing streak. The loss for the Angels was their sixth in eight games.

Gutierrez watched the first nine innings from the bench but was called upon to pinch hit for Seth Smith in the 10th.

Angels left-handed reliever Jose Alvarez entered the game to start the 10th and gave up a leadoff single to Ketel Marte. Norichika Aoki sacrificed Marte to second before Gutierrez lined a single to center off Alvarez (0-1) to score Marte and give the Mariners a lead.

Nelson Cruz hit a two-run homer later in the inning, also off Alvarez, to give the Mariners and closer Steve Cishek a cushion entering the bottom of the 10th. Cishek finished it for his fourth save and Joel Peralta (1-0) got the win with a scoreless ninth.

Angels starter Nick Tropeano settled in after a rough start and managed to get through 5 1/3 innings, allowing two runs, four hits and four walks. He left with one out in the sixth having made 96 pitches, a pitch count elevated by a rocky first inning during which the Mariners scored their runs against him and forced him to throw 26 pitches.

Mariners starter Hisashi Iwakuma was much more pitch efficient and managed to go eight innings, allowing two runs, six hits and one walk while making just 89 pitches. The Angels' two runs against Iwakuma came on solo homers by Kole Calhoun in the fourth and C.J. Cron in the fifth.

The Angels used four relievers -- Greg Mahle, Fernando Salas, Joe Smith and Huston Street -- to keep the Mariners scoreless through the ninth.

Peralta took over for Iwakuma to start the ninth and retired Mike Trout, Albert Pujols and Calhoun in order to send the game into extra innings.

Tropeano struggled at the outset as the Mariners loaded the bases with none out to begin the game. He escaped cheaply enough, though, as the Mariners scored only two runs, both on sacrifice flies by Nelson Cruz and Adam Lind.

The Angels threatened in the bottom half against Iwakuma when Yunel Escobar and Rafael Ortega singled to open the inning. But Iwakuma got Trout to fly out and induced a double-play grounder from Pujols to end the inning.

Iwakuma settled in from there, not allowing another hit until Trout opened the fourth with a bloop single. Pujols grounded into another double play, which turned out to be big because Calhoun followed with a home run to cut the Mariners' lead to 2-1.

The Angels got even in the fifth when Cron hit his first homer of the season, blasting a 0-1 pitch from Iwakuma over the center field wall to tie the score at 2-2.

NOTES: Mariners RHP Felix Hernandez was scratched from his scheduled start Friday because of the flu and replaced by RHP Hisashi Iwakuma. Hernandez is listed as the scheduled starter for Saturday's game, but he could be pushed back again if he isn't feeling up to it. If Hernandez can't go, LHP Mike Montgomery is expected to start. ... Angels CF Mike Trout has faced Hernandez more than any other pitcher in the majors, hitting .354 (23 for 65) against him. Trout also has struck out against Hernandez more (21 times) than any other pitcher. ... Angels LHP C.J. Wilson, out all season with a sore shoulder, played catch from 90 feet before the game. There is no timetable for his return. ... Mariners manager Scott Servais returned to Angel Stadium for the first time since serving as assistant general manager from 2011 through last season.