David Ortiz homered for the third consecutive night and the Boston Red Sox scored seven runs in the fifth inning on the way to a 10-6 win over the Los Angeles Dodgers in an interleague game on Friday night.

Dodgers outfielder Manny Ramirez went 1-for-5 with a single in his highly-anticipated return to Boston for the first time since he was traded by the team in 2008. Ramirez was greeted with mixed responses throughout the night.

Some fans started ā€¯Manny, Mannyā€¯ chants and others booed and Ramirez made the final out of the game, striking out looking on a curveball by Daniel Bard.

The Red Sox pounded out 13 hits in the game. They took a 3-0 lead in the first inning on homers by Ortiz and J.D. Drew off Carlos Monasterios (3-2).

The Dodgers tied the game in the third inning on an error by winning pitcher Felix Doubront (1-0) and an RBI triple by Matt Kemp. Kemp then scored the tying run on a ground out.

But Boston broke the game open with the big fifth inning as the first eight batters reached base. Adrian Beltre hit a two-run homer in the inning, Kevin Youkilis had an RBI double and Darnell McDonald singled in another run. Dustin Pedroia and Marco Scutaro also had RBIs in the frame.