CINCINNATI -- Dae-Ho Lee homered and also had a two-run single during a four-run seventh as the Seattle Mariners rallied for a 8-3 victory over the Cincinnati Reds in the opener of a three-game interleague series Friday night at Great American Ball Park.

The game was delayed 45 minutes due to rain.

Seattle's offense sputtered for six innings before erupting for seven runs in the final three frames.

Zack Cozart hit his fifth home run for Cincinnati (15-26) which has lost 11 of 13 meetings with the Mariners.

Right-hander Dan Straily shutout the Mariners on three hits through five innings. But, the pitches began to pile up for Straily and Seattle finally broke through in the sixth.

With Cincinnati leading 3-0, Robinson Cano was hit by a pitch and later scored on Kyle Seager's double.

A tremendous diving grab in center by Billy Hamilton on Adam Lind's liner prevented a big sixth inning by the Mariners. Straily greeted Hamilton with a hug and a smile before heading into the dugout after allowing a run and four hits through six.

But, Straily was done after 110 pitches and the game was turned over to the Reds' bullpen which owned a 6.48 ERA coming in.

Blake Wood (3-1) walked Seth Smith with the bases loaded to make it a one-run game in the seventh. Tony Cingrani hit Cano to force home the tying run.

It was the 10th blown save in 14 opportunities for the Reds.

Lee capped the rally with a clutch hit to drive in two runs putting Seattle ahead 5-3.

In the ninth, Nelson Cruz hit his 250th career homer and Lee added a solo shot to cap the scoring for Seattle (24-17). Hisashi Iwakuma (2-4) allowed three runs over six innings to earn the victory.

NOTES: Reds RHP Tim Adleman was placed on the 15-day disabled list with a strained left oblique which caused him to leave Thursday's start in the fourth inning. ... The Reds recalled OF Steve Selsky from Triple-A Louisville on Friday. He struck out as a pinch-hitter in the sixth in his big-league debut. ... Mariners minor league RHP Jose Luis Santiago was suspended 76 games Friday for testing positive for a banned substance. ... The Mariners' .846 winning percentage against the Reds is the fourth highest in major league history since 1900, minimum 10 games.