Andrew Luck threw four touchdown passes and Adam Vinatieri moved within five points of the NFL's all-time scoring record during the Indianapolis Colts' 37-5 victory over the visiting Buffalo Bills on Sunday at Lucas Oil Stadium.

Marlon Mack rushed for a career-high 126 yards and a touchdown and added 33 yards and another score receiving for the Colts (2-5), who snapped a four-game losing streak and won at home for the first time this season.

Indianapolis scored 25 points off of five Buffalo turnovers. Mike Mitchell had a forced fumble and an interception that led to 10 of the Colts' 24 points in the second quarter.

The Bills (2-5) failed to score a touchdown for the third time this season. They were shut out in the first half for the fourth time.

Colts wide receiver T.Y. Hilton returned after missing two games with a hamstring injury and caught two touchdown passes. Luck completed 17 of 23 passes for 156 yards, his lowest totals of the season. He also threw a touchdown to tight end Erik Swoope.

Vinatieri made a 36-yard field goal and two extra points to get closer to Morten Anderson's record of 2,545 career points, but missed two PATs and had another nullified by a Bills penalty.

Buffalo's points came on a 34-yard Stephen Hauschka field goal and an Indianapolis shotgun snap that rolled out of the end zone for a safety.

In his first start for the Bills, Derek Anderson was 20 of 31 passing for 175 yards but threw three interceptions and lost a fumble. Buffalo signed Anderson earlier this month to mentor rookie Josh Allen, but turned to the 35-year-old journeyman after an elbow sprain sidelined Allen and backup Nathan Peterman proved ineffective.

Buffalo also played most of Sunday's game without Pro Bowl running back LeSean McCoy, who was ruled out after getting upended and hitting his head on the turf running to the sideline on the opening drive.

--Field Level Media