PITTSBURGH -- The aim was the same, but the second time was the winner.

Adam Frazier hit a two-out, two-run homer to right in the ninth inning Wednesday night as the Pittsburgh Pirates halted a seven-game losing streak with a 6-4 win over the Milwaukee Brewers at PNC Park.

In the third, Frazier hit a triple to nearly the same spot, but it struck the wall for his first two RBIs.

"I didn't get enough of the first one," Frazier said. "I just thought I could get that (second one) into the first row and get it out of there."

His winning hit came against Brewers reliever Corey Knebel (1-3). It was Frazier's third career walk-off home run.

Starling Marte was 2-for-4 with an RBI for Pittsburgh (69-84), which had lost 12 of its previous 13.

The Brewers (81-71) missed a chance to sweep the three-game series as well as a chance to move into a tie with the Colorado Rockies for the second National League wild-card spot. They remain 3 1/2 games behind the first-place Chicago Cubs in the NL Central after the Cubs lost.

Domingo Santana and Jesus Aguilar each hit solo homers for Milwaukee, which next has a four-game showdown at home against the Cubs.

"We've had a lot of games where (Knebel) just shoved it and gave us the win," Milwaukee's Eric Thames said. "It happened. It's baseball. Have to come back and beat the Cubs tomorrow."

The Pirates tied it 4-4 in the eighth when Andrew McCutchen doubled and scored an out later on Knebel's throwing error after the pitcher fielded a grounder barehanded.

"When Knebel made that error in the bottom of the eighth, that was pretty big for us," Frazier said. "It got us going a little bit, and you could kind of feel the energy on their side let down a little bit for the first time in the series."

Knebel didn't second-guess his fielding.

"Had to be quick, and (the) ball just slipped," he said. "I wouldn't have changed it."

Pirates closer Felipe Rivero (5-2) pitched the ninth.

Pittsburgh starter Steven Brault, coming off his first major league win last week, gave up two runs and four hits, with a walk and three strikeouts, in five innings. Two of the hits were homers.

In a pre-planned move because there aren't enough starts to go around with the Pirates' collection of pitchers, Tyler Glasnow relieved Brault in the sixth.

Glasnow, trying to gain some traction in the major leagues after dominating in Triple-A, got out of the sixth OK. However, he walked four batters in the seventh, although pinch runner Quintin Berry was caught trying to steal second. Glasnow ultimately was charged with two runs without giving up a hit.

"Just try to forget about this one," Glasnow said.

A.J. Schugel came on and gave up an RBI double to Eric Thames for a 3-3 tie, then walked Stephen Vogt -- the Brewers' fourth straight pinch hitter --with the bases loaded to give Milwaukee a 4-3 lead.

Brewers right-hander Aaron Wilkerson made his first career start. He faced the minimum through two innings but didn't make it out of the third, when he gave up three runs. Overall, Wilkerson allowed four hits with one walk and no strikeouts in 2 1/3 innings. He threw only 40 pitches.

Milwaukee got solo homers in the second and third innings.

Aguilar blasted a 440-footer, his 15th home run of the season, that landed in the Pirates' bullpen in center and then hopped through an open door.

In the third, Santana hit his second homer in as many nights, this one landing in the stands in right for a 2-0 Brewers lead. Santana's 27th homer came with two outs.

"Whenever I'm giving up home runs, it means I'm leaving the ball over the plate," Brault said. "I pride myself on the fact I don't give up too many. The first one was hit so far, it's hard to be really bummed out about it. The second one, that's tough."

Pittsburgh broke a scoreless streak of 21 1/3 innings and took a 3-2 lead in the bottom of the third on Frazier's one-out, two-run triple and Marte's ensuing RBI single. Marte's hit chased Wilkerson.

"To get that hit and drive in a couple, yeah it was a breath of fresh air," Pittsburgh manager Clint Hurdle said of Frazier's triple.

NOTES: RHP Aaron Wilkerson was the 13th starter for Milwaukee this season. ... Milwaukee RHP Jimmy Nelson, who underwent shoulder surgery Tuesday, will miss an undetermined amount of the 2018 season, GM David Stearns said. ... Pittsburgh LHP Felipe Rivero, the team's closer, pitched the ninth inning for the win, just his third appearance in 16 days.