Parker Jackson-Cartwright scored 14 points, Rawle Alkins had 12 and Deandre Ayton added 10 for the Wildcats (25-7), who avenged one of their four conference regular-season losses.
George King scored 19 points and Lucas Siewert had 16 for the Buffaloes (17-15), who had lost four of five before beating Arizona State in the first round of the tournament.
Arizona will UCLA on Friday after the Bruins beat Stanford 88-77. UCLA beat the Wildcats in Tucson on Feb. 8 in their only meeting this season, the Wildcats' only home loss.
The Wildcats led by three points with 13 minutes remaining before taking control with a 14-0 run fueled by eight points from Ristic and two Trier free throws after a technical foul on the Colorado bench for a 58-41 lead with 10:30 remaining. They led by as many as 18.
Colorado played the final 13:08 without freshman point guard McKinley Wright IV, who had eight points, five assists and four rebounds before suffering an apparent ankle injury during a scramble for a rebound under the Colorado basket.
Wright had 16 points and 10 assists in the Buffaloes' 80-77 victory over Arizona in Boulder on Jan. 6, and he had 20 points, 11 assists and eight rebounds in a 97-85 first-round victory over Arizona State.
Trier made 10-of-10 free-throw attempts, and Ristic had his seventh double-double. He has scored in double figures in 13 of his last 15 games.
The Wildcats, third in NCAA Division I with a 51.0 shooting percentage, made only 43.9 percent from the field but had a 36-27 rebounding advantage and forced 15 turnovers. They committed eight.
Ayton, who joined Shareef Abdur-Rahim and Kevin Love as the only Pac-12 players to win player of the year and freshman of the year, made only 4-of-14 field-goal attempts and had six rebounds in 25 minutes before fouling out.
--Field Level Media
Colorado | Arizona | |
George King 19 | Scoring | Allonzo Trier 22 |
McKinley Wright IV 5 | Assists | Parker Jackson-Cartwright 4 |
Tyler Bey 9 | Rebounds | Dusan Ristic 11 |
Lucas Siewert 6 | Free Throws Made | Allonzo Trier 10 |
George King 2 | Steals | Rawle Alkins 4 |
Dallas Walton 2 | Blocks | DeAndre Ayton 3 |