Chiefs 23, Chargers 20: Cairo Santos kicked his third field goal, a 48-yarder with 21 seconds to play in the fourth quarter, as visiting Kansas City snapped San Diego's five-game winning streak.

Alex Smith threw for 221 yards and a touchdown on 19-of-28, completing passes of 19 and 16 yards to move the Chiefs (3-3) from their own 8-yard line with 1:51 remaining into position for Cairo's winning kick. Jamaal Charles rushed for 95 yards and a score for Kansas City, which converted 7-of-14 third-down attempts and held the ball for 39 minutes.

Philip Rivers finished 17-of-31 for 205 yards with a pair of touchdowns and a last-second interception for the Chargers (5-2), who suffered their first loss since an 18-17 setback to Arizona in Week 1. Tight end Antonio Gates had three receptions for 61 yards and a touchdown for San Diego, which fell to 6-2 in its last eight against the Chiefs.

Kansas City chewed up nearly 6 1/2 minutes on its opening drive of the second half, resulting in Santos' 40-yard field goal, before Smith capped an 11-play march that ate up 7:43 with an 11-yard scoring pass to Anthony Sherman with 14:50 remaining for a 20-14 lead. Rivers guided the Chargers on consecutive scoring drives, culminating with field goals of 24 and 48 yards by Nick Novak to tie it at 20-20 with 1:57 to play.

Charles answered Rivers' 1-yard scoring pass to John Phillips by zig-zagging 16 yards for a TD on the first play of the second quarter and plowing over cornerback Brandon Flowers, who suffered a concussion on the play. A 28-yard field goal by Santos put the Chiefs ahead with 3:13 left in the second, but Rivers needed only 41 seconds to cover 80 yards, capping the drive with back-to-back 27-yard completions to Gates for a 14-10 halftime advantage.

GAME NOTEBOOK: Rivers' two scoring passes gave him 238 for his career, surpassing Jim Kelly for 20th place on the NFL's career list. He also set a franchise record with a TD pass in his 27th straight game. ... Charles' 16-yard scoring run in the second quarter gave him 53 rushing yards for the day, moving him one past Priest Holmes (6,070) for first place on the franchise list. ... Gates has 15 touchdown catches versus the Chiefs - his most against any opponent - and closed within 29 yards of eclipsing Hall-of-Famer Lance Alworth (9,584) for first in team history. ... Novak set a club record with his 30th and 31st consecutive field goals.