The Cavaliers will visit the Toronto Raptors on Tuesday night in Game 1 of the Eastern Conference semifinals.
James, who hit 16 of 25 shots and 11 of 15 free throws, contributed nine rebounds, seven assists and four steals.
"I'm burnt right now," he told reporters postgame. "I'm not thinking about Toronto right now until tomorrow. I'm ready to go home. Can we? I'm tired. I want to go home."
Cleveland center Tristan Thompson, making his first start of the series, delivered a double-double with 15 points and 10 rebounds. Kevin Love scored 14 points, hitting four 3-pointers, for the Cavs.
Cleveland point guard George Hill, who missed the previous three games with back spasms, didn't play in the first half but scored 11 points in the final two quarters.
Victor Oladipo topped the Pacers with 30 points, 12 rebounds and six assists. Point guard Darren Collison added 23 points for the Pacers, and forward Thaddeus Young had 14 points and 10 rebounds.
"Nobody thought we were going to be here," Oladipo said. "I feel like we've earned our respect from everyone."
Oladipo's driving layup cut the Cavaliers' lead to 100-96 with 50.1 seconds remaining. James' layup pushed the lead to 102-96. After an Oladipo miss, James hit two free throws with 23 seconds left to seal it.
The Pacers shot 45 percent from the field while the Cavaliers hit 43.2 percent. The Cavs had a 44-37 rebounding edge for the game.
After leading by 11 at halftime, Cleveland's advantage was cut to 76-74 after three quarters. James, experiencing some cramping, had gone to the locker room with one minute left in the third quarter. He didn't return until 8:04 was left in the fourth quarter with the Cavaliers leading 86-78.
"It felt like a Game 7," James said. "It was like, your mind is thinking like, 'OK, besides the two I played in the Finals, you start thinking like, is this it? Could this be it?' That's just human nature. And then the other side of my brain was like, 'Let's go make something happen. Let's go, that's what you here for. You're here to make plays, you're the leader.'"
Indiana used an 18-2 run to take a 61-58 lead in the third quarter. Bojan Bogdanovic's 3-pointer gave the Pacers their first lead at 59-58 with 7:13 to go in the quarter.
James scored 26 points to propel the Cavaliers to a 54-43 halftime lead.
The Pacers sank 54.8 percent from the field in the first half compared to 43.8 percent for the Cavaliers. However, Indiana had eight turnovers while Cleveland had zero in the first half. The Cavs scored 10 points off those turnovers. Cleveland had an 11-2 edge in offensive rebounds, 24-17 in overall rebounds.
For the game, the Cavaliers had 12 turnovers, one more than the Pacers.
The Pacers used a 10-0 run to cut the deficit to 35-31 in the second quarter before Cleveland rebuilt the advantage.
James hit all five of his shots in the first quarter to help Cleveland to a 31-19 advantage after the opening 12 minutes.
Thompson had six points and seven rebounds in 11 minutes in the first quarter to give the Cavs a lift.
--Field Level Media
Indiana | Cleveland | |
Victor Oladipo 30 | Scoring | LeBron James 45 |
Victor Oladipo 6 | Assists | LeBron James 7 |
Victor Oladipo 12 | Rebounds | Tristan Thompson 10 |
Victor Oladipo 6 | Free Throws Made | LeBron James 11 |
Victor Oladipo 3 | Steals | LeBron James 4 |
N/A | Blocks | Jeff Green 1 |
Team | Points | FG% | 3PM-3PA | FTM-FTA | Assists | Rebounds | Blocks | Steals | Turnovers |
Indiana | 101 | 45.0 | 10-31 | 19-24 | 15 | 37 | 0 | 6 | 11 |
Cleveland | 105 | 43.2 | 10-29 | 31-40 | 18 | 44 | 4 | 6 | 12 |