Machado ripped a 1-0 fastball from Pedro Araujo (1-2) for his first homer of the season.
John Hicks hit a three-run homer for Detroit in the eighth. Miguel Cabrera homered on his 35th birthday and Jeimer Candelario also rapped a solo shot in the Tigers' second straight win after five losses.
Shane Greene (1-0) blew a save opportunity in the top of the ninth, giving up a homer to Luis Sardinas, but wound up with the win.
Tigers starter Matthew Boyd allowed just one run on two hits with six strikeouts in 6 1/3 innings. Boyd became the first Tigers left-hander since at least 1908 to throw six or more innings and allow one or no runs in his first three starts of the season.
Manny Machado had two hits, a run scored and an RBI for Baltimore, while Danny Valencia added a solo homer.
Valencia put the Orioles on the board with his one-out homer in the second.
Candelario evened the score with his homer to right to lead off the third.
Cabrera gave Detroit a 2-1 lead in the bottom of the sixth. Leading off, he jumped on a 1-1 slider and ripped a liner that just cleared the left-field wall.
The Orioles grabbed the lead in the eighth. Trey Mancini smacked a leadoff double and Craig Gentry followed with a bunt single. Machado's single up the middle knocked in Mancini and Adam Jones' sacrifice fly brought home Gentry. Chris Davis banged a single off the left-field wall, scoring Machado for a 4-2 advantage.
Detroit regained the lead at 5-4 in the bottom of the inning on Hicks' first homer. He jumped on the first pitch he saw from reliever Darren O'Day and drilled it over the left-field wall.
Pinch hitter Sardinas golfed a pitch over the right-field wall leading off the ninth to tie it.
--Field Level Media
Baltimore | Detroit | |
Kevin Gausman | Player | Matthew Boyd |
No Decision | W/L | No Decision |
6.0 | IP | 6.1 |
4 | Strikeouts | 6 |
9 | Hits | 2 |
3.00 | ERA | 1.42 |
Baltimore | Detroit | |
Manny Machado | Player | Miguel Cabrera |
2 | Hits | 2 |
1 | RBI | 1 |
0 | HR | 1 |
3 | TB | 6 |
.500 | Avg | .500 |