Broncos 41, Giants 23: Peyton Manning threw for 307 yards and two touchdowns and visiting Denver pulled away in the fourth quarter in the third edition of the Manning Bowl.

Knowshon Moreno rushed for 93 yards and a pair of touchdowns and Trindon Holliday returned a punt 81 yards for a score to cap a blitz of three touchdowns in 5 minutes, 12 seconds as the Broncos (2-0) extended their regular-season winning streak to 13 games - the longest active run in the NFL.

Eli Manning finished 28-of-49 for 362 yards with one touchdown and four interceptions for New York (0-2), which managed a feeble 23 yards rushing en route to having its three-game home winning streak snapped. Brandon Jacobs scored on a 1-yard run and Josh Brown kicked three field goals for the Giants, who trailed 10-9 at halftime.

Peyton Manning, who improved to 3-0 all-time against his younger brother, capped a second-half opening drive with a 2-yard slant pass to Wes Welker, but New York answered with an 81-yard march that Jacobs finished with a 1-yard plunge to keep it a one-point deficit.

From there it was all Denver, as Moreno went around right end for 25 yards in the final minute of the third, and Chris Harris' interception led to Julius Thomas' 11-yard scoring reception for a 31-16 edge with 12:19 to play. Holliday made it a runaway with his fifth career touchdown return just over two minutes later.

GAME NOTEBOOK: Manning became the third quarterback in league history to surpass 60,000 career passing yards, joining Brett Favre and Dan Marino. He is also the fastest to reach the milestone. ... Giants WR Victor Cruz had eight catches for 118 yards and Hakeem Nicks added four receptions for 83 yards despite suffering a dislocated finger early in the second quarter. ... Moreno had his first game with multiple touchdowns since Oct. 24, 2010, while Jacobs - who was re-signed by New York on Tuesday after spending last season with San Francisco - had his first rushing TD since Dec. 11, 2011.