DENVER -- Payback for Nolan Arenado came quickly.

Arenado hit a three-run homer in a four-run seventh inning Tuesday night as the Colorado Rockies beat the Detroit Tigers 7-3.

Arenado's 30th homer of the season came against Tigers reliever Walker Saupold. They faced each other Monday night with the bases loaded, one out in the sixth and the Tigers ahead 4-3. Arenado struck out.

On Tuesday, Arenado drove a 1-0 fastball from Saupold an estimated 436 feet to left-center, boosting his major-league-leading RBI total to 111.

"Obviously yesterday I feel I let the team down with my bases loaded at-bat where I struck out," said Arenado, who had three hits in his previous 23 at-bats and was 0-for-10 with runners in scoring position when he batted Tuesday against Saupold. "To be able to come up and help them out today feels good.

"I feel like I've been taking good swings. I'm staying the course and try not to get down. There's only a month left. Last thing I want to do is start getting down on myself."

On Monday, Saupold struck out Arenado on four pitches, starting him off with a curveball for a called strike and finishing him with swinging strikes on a fastball on the inner portion of the plate followed by a slider away.

"I got ahead with a first-pitch breaking ball like I did the previous night," Saupold said. "The fastball didn't get in enough, and he made me pay."

Arenado's blast capped a rally that included two singles, a walk and a sacrifice fly. Colorado's big inning came after the Tigers tied the game at 3 in their half of the seventh on Mikie Mahtook's two-run homer.

The Rockies entered the game hitting only .223 this month with runners in scoring position and .181 in their past 11 games -- seven of them losses. Stringing hits together and coming up with a timely knockout hit had become challenging.

The game-winning rally began when Jonathan Lucroy completed an 11-pitch at-bat with a single, then scampered to third when Trevor Story followed with a single.

"You have to tip your cap to him," Tigers starter Michael Fulmer said of Lucroy. "I thought he fouled off some good pitches, took some good pitches as well."

Pinch hitter Carlos Gonzalez, who was not in the lineup for the second consecutive day because of a sore left ankle, lifted a sacrifice fly to center to give the Rockies a 4-3 lead.

The sacrifice fly finished the outing for Fulmer (10-12), who gave up five runs in 6 1/3 innings and lost his sixth consecutive decision.

After Charlie Blackmon grounded into a forceout against Daniel Stumpf, Saupold entered and walked DJ LeMahieu. Arenado followed with his three-run shot.

"We've been looking for that inning for a while," Gonzalez said. "We haven't scored a lot of runs, so that was big, especially after they tied the game and the great performance by (Rockies starter German) Marquez. You just want to go out there and try and regain the lead again, and it was a perfect scenario."

Marquez allowed three runs and seven hits in 6 1/3 innings with one walk and a career-high-tying 10 strikeouts. He also notched 10 strikeouts July 29 at Washington. In his past nine home starts, Marquez is 6-0 with a 3.26 ERA.

Marquez gave was very much in control for six innings, giving up one run in that span on John Hicks' double in the fifth before Mahtook's 10th homer of the season on a 1-1 slider.

Jose Iglesias then singled, beating Marquez's throw on a broken-bat nubber and ending Marquez's highly efficient 87-pitch outing that included 63 strikes. Pat Neshek (5-3) came on and retired the two batters he faced.

Lucroy, a veteran catcher, gave high praise to the 22-year-old Marquez.

"He's the best pitcher I've ever caught at that age," Lucrory said. "I keep thinking, 'His last name, Marquez. I keep thinking marquee.' He's going to be a marquee pitcher. I really believe it. He's only going to continue to get better."

LeMahieu gave the Rockies a 1-0 lead in the first when he hit an opposite-field homer into the right field stands. He connected on Fulmer's full-count 96 mph fastball for his seventh of the season and third in four games.

Gerardo Parra sliced a two-run, two-out single to left in the third, putting the Rockies ahead 3-0. The hit scored Blackmon, who reached base on an infield single, and LeMahieu, who walked. Both runners moved up on Arenado's slow grounder to third.

NOTES: Tigers 1B Miguel Cabrera did not play because of lower back tightness that caused him to leave the Monday game in the fifth inning. ... Rockies LHP Tyler Anderson (left knee surgery) is scheduled to throw three innings or 40-45 pitches Thursday for Triple-A Albuquerque in his second rehab start. ... Plate umpire Mike Everitt was hit with a Michael Fulmer warm-up pitch before the bottom of the first, and second base umpire Tom Woodring took over behind the plate after a 12-minute delay. ... Rockies prospects who will play for Salt River in the Arizona Fall League include RHPs Yency Almonte, Shane Broyles, James Farris and Zach Jemiola, C Dom Nunez and OF Yonathan Daza. The Tigers will send RHPs Adam Ravenelle, Zac Reininger, Spencer Turnbull, INFs Kody Eaves and A.J. Simcox and OF Cam Gibson to play for Mesa in the AFL.