Kyle Schwarber and J.T. Realmuto hit home runs in a five-run sixth inning as the Philadelphia Phillies scored a 6-2 victory over the host San Diego Padres on Thursday.

Padres right-hander Joe Musgrove entered the series opener against the Phillies with an 8-0 record and a 1.59 ERA -- and he didn't allow a hit through 4 1/3 innings on Thursday. Then seven of the next nine Phillies got hits.

Philadelphia scored once in the fifth to tie the game then got a two-run homer from Schwarber and a three-run shot from Realmuto in the sixth, ending Musgrove's run of 12 straight quality starts. In fact, the Phillies' six runs equaled the number of runs Musgrove (8-1) had allowed in his last six starts combined.

Musgrove lasted six innings and yielded seven hits and a walk while striking out one.

The Padres took a 1-0 lead in the second on Eric Hosmer's home run off Phillies starter Ranger Suarez, who improved to 6-4 by holding the Padres to two runs on seven hits and two walks. He struck out three over 7 1/3 innings -- his longest outing of the season.

Realmuto got the action going against Musgrove with a one-out single in the fifth -- the Phillies' first hit. Realmuto advanced to second on a wild pitch and tied the game on Odubel Herrera's single to left off the glove of shortstop Ha-Seong Kim.

Bryson Stott doubled to open the Phillies' sixth and immediately came around when Schwarber struck his 20th homer of the season over the fence in straightaway center. After Rhys Hoskins popped out to first, Bryce Harper and Nick Castellanos had back-to-back singles. Realmuto then hit his fourth homer of the season -- into the right field stands.

Musgrove's ERA climbed from 1.59 to 2.12.

Trent Grisham opened the Padres' eighth with a single off Suarez, moved to third on Austin Nola's double and scored on Jorge Alfaro's groundout to first against reliever Seranthony Dominguez.

--Field Level Media