CLEVELAND -- Nick Castellanos homered among his three hits and had five RBIs as the Detroit Tigers cruised to a 12-2 victory over the Cleveland Indians on Wednesday afternoon at Progressive Field.

With the win, Detroit snapped its 11-game losing streak to Cleveland - with all 11 setbacks coming in 2016. Cleveland also saw its 14-game home winning streak end as Wednesday's loss was the Indians' first at Progressive Field since a 7-3 setback to Texas on May 31.

Cameron Maybin also homered for the Tigers, who are 5-2 in the first seven contests of an 11-game road trip to Tampa Bay, Cleveland and Toronto.

Michael Fulmer (9-2) pitched six innings, giving up two runs (one earned) on five hits with two strikeouts and two walks.

Cleveland starter Josh Tomlin (9-2) retired the first nine batters he faced in the game and then couldn't get anyone out. Tomlin gave up eight runs and seven hits, including two home runs, in his last 1 2/3 innings.

The Indians had an early 2-0 lead then saw the Tigers score 12 unanswered runs. In the first inning, Jose Ramirez doubled, went to a third on an error by Tigers right fielder Steven Moya, and scored on a sacrifice fly by Lonnie Chisenhall.

In the third inning, Chris Gimenez singled, went to third on a single by Carlos Santana and scored on a sacrifice fly by Francisco Lindor.

But that was it for the Indians, who were held to two runs after outscoring Detroit 77-24 in the initial 11 meetings.

Trailing 2-0, the Tigers blew it open in the fourth and fifth innings when they sent a combined 15 men to the plate and eight of them scored. In the fourth, Ian Kinsler led off with a single and Maybin bounced a fly ball off the left-field foul pole for a two-run home run to tie the game.

Tomlin retired Miguel Cabrera on a fly out, but Victor Martinez doubled off the center-field wall. Martinez went to third on a single by Castellanos, and Martinez scored on a sacrifice fly by Justin Upton, giving the Tigers a 3-2 lead.

In the fifth inning Tomlin struck out the first two batters he faced, but then the Tigers went to work. Kinsler reached on an infield single and Maybin walked. Cabrera lined a long single off the right field wall, scoring Kinsler and Maybin and extending the lead to 5-2.

Lindor, Cleveland's All-Star shortstop, then booted a grounder hit by Martinez for an error. Castellanos hit Tomlin's next - and last - pitch over the wall in center field for a three-run home run.

The Tigers added two more runs in the seventh inning on a two-run double by Castellanos. Castellanos did not play in Tuesday's contests due to flu-like symptoms, but went 5-for-9 with two doubles, two home runs and seven RBIs in the series.

NOTES: The Tigers recalled RHP Bobby Parnell from Triple-A Toledo. In 30 relief appearances with Toledo, Parnell had no decisions and a 3.07 ERA. Parnell replaces RHP Buck Farmer, who was optioned to Toledo. ... 1B Miguel Cabrera's All-Star selection was his seventh as a member of the Tigers. That ties Cabrera with Jim Bunning for the fourth-most All-Star selections in Tigers history. Cabrera is the first Detroit position player to go to seven consecutive All-Star games since C Bill Freehan went to 10 straight from 1964-73. ... Cleveland's 14-game home winning streak is the longest home winning streak by any team in the American League since the Indians won 14 games in a row at home in April and May of 2011. ... Indians 3B Juan Uribe's next home run will be the 200th of his career.