PITTSBURGH -- Topping off a game of late comebacks and wasted opportunities, Yasiel Puig homered leading off the 12th inning to provide the Los Angeles Dodgers with yet another victory, 6-5 over the Pittsburgh Pirates on Monday at PNC Park.

Puig's homer, his 22nd of the year, came on a 1-0 fastball from Dovydas Neverauskas (1-1), the sixth Pirates pitcher.

Puig was asked about his approach to hitting against Neverauskas, whom he had never faced.

"Just try to put the ball in play and wait on his fastball," he said through a translator. "I know it was his best pitch, and that's the pitch I struggle with."

Luis Avilan (2-1) got the win, and Ross Stripling, the eighth Dodgers pitcher, earned his second save. Each threw a scoreless inning.

A last-ditch Pirates rally failed in the 12th when rookie Max Moroff flied out with runners on first and second.

The Dodgers, whose 88-35 record is the best in baseball by far, erased a 3-0 Pittsburgh lead with five runs in the seventh inning, highlighted by Curtis Granderson's grand slam off Pittsburgh starter Gerrit Cole.

A 14-year veteran, Granderson was traded by the New York Mets to the Dodgers on Friday. In three games with the Dodgers, he has two home runs.

"Grandy, that's what he does," Dodgers manager Dave Roberts said. "He puts together good at-bats, gets big hits. We've seen that from the other side from him."

Josh Harrison's one-out RBI double for the Pirates off reliever Pedro Baez cut the lead to 5-4 in the eighth. Andrew McCutchen and David Freese then walked, loading the bases.

Josh Bell hit into a force play, scoring Harrison with the tying run, and John Jaso walked. The bases were loaded again, and Brandon Morrow replaced Baez to face Jordy Mercer. The Pirates shortstop flied out.

The Dodgers had a big chance in the 10th when Pirates reliever Joaquin Benoit walked the bases loaded, but Chris Taylor flied out to right field to end the threat.

Kenley Jansen, the Dodgers' closer, came in to pitch the 10th with the game tied. It is something he doesn't do often, but he was effective, giving up a two-out single to Bell but striking out two and keeping the Pirates off the board.

"It was more of an aggressive move to get him in a tie game on the road," Roberts said. "I felt to extend the game he gave us the best chance. ... For Kenley to take the ball in a tie game says a lot about him and his unselfishness."

The Pirates took a 3-0 lead on back-to-back homers by Jose Osuna and Sean Rodriguez in the second inning and a home run by Harrison in the third. All came off Dodgers starter Alex Wood, who was seeking to extend his record to 15-1.

Wood gave up three runs on five hits in six innings. The left-hander said he has been dealing with a flare-up of a shoulder injury that put him on the disabled list earlier in the season. He said it is not as serious this time and that is did not contribute to the home runs.

"Just bad pitches," Wood said.

Cole retired 12 of 13 hitters before hitting Justin Turner with one out on the sixth. The Dodgers loaded the bases with two outs for Adrian Gonzalez, who was two hits shy of 2,000 in his career. Gonzalez swung at Cole's first pitch and blasted it to center field, where McCutchen caught it at the wall. The Pirates still led, but that would soon change.

Cole yielded five runs on eight hits in 6 1/3 innings. Asked if perhaps he kept Cole in the game too long in the seventh, Pirates manager Clint Hurdle replied, "I still know he's got pitches and he's our ace. I still felt he was the best equipped to get out of that situation."

The Dodgers played without Cody Bellinger, whose 34 homers and 79 RBIs make him the favorite for National League Rookie of the Year honors. He is nursing a mild ankle sprain.

NOTES: Dodgers LHP Clayton Kershaw, who has missed the past month with a strained back, threw 55 pitches in four innings, one more inning than planned, in a simulated game Monday. He is scheduled for a rehab start Saturday at Triple-A Oklahoma City before likely being activated next week. ... OF Sean Rodriguez has hit three homers in 12 games since rejoining the Pirates after a trade with Atlanta. ... Dodgers SS Corey Seager went 1-for-6 but extended his hitting streak to 10 games.