Wideout Travis Fulgham and linebacker Alex Singleton scored their first career NFL touchdowns on consecutive plays from scrimmage midway through the fourth quarter Sunday night, helping the visiting Philadelphia Eagles shock the host San Francisco 49ers 25-20 at Levi's Stadium in Santa Clara, Calif.

Carson Wentz threw for one score and ran for another as the Eagles (1-2-1) took over first place in the NFC East with their first win of the season.

The loss dropped the defending NFC champion 49ers (2-2) into third place, two games behind the Seattle Seahawks in the NFC West, and a game behind the Los Angeles Rams, after a second straight home defeat.

49ers standout tight end George Kittle returned from a two-week absence with a knee injury to catch 15 passes for 183 yards, including a 5-yard touchdown from Nick Mullens that gave San Francisco a 14-8 lead with 8:26 left in the third quarter.

After a Jake Elliott 35-yard field goal had cut the 49ers' lead in half at 14-11, Eagles cornerback Cre'von LeBlanc sacked Mullens, forcing a fumble that defensive tackle Malik Jackson recovered at the San Francisco 42 with 10:06 to play.

Following six plays that produced two first downs despite gaining no net yardage, Wentz found Fulgham deep down the left sideline for the go-ahead score with 5:50 remaining in the game.

Mullens had plenty of time to rally the 49ers, but his next pass went right into the hands of Singleton, who raced 30 yards into the end zone for a 25-14 lead with 5:42 to go.

C.J. Beathard was summoned to replace Mullens at quarterback, and he marched the 49ers quickly down the field for a touchdown on a 1-yard plunge by Jerick McKinnon with 2:02 to play. But a two-point conversion pass failed, leaving the 49ers down 25-20.

San Francisco got one more possession with 1:40 left, but with no timeouts, got only as far as the Philadelphia 33 before a fourth-and-10 pass by Beathard fell incomplete with no time left.

Wentz finished 18 of 28 for 193 yards with one interception and one touchdown. Eagles wide receiver Greg Ward Jr. had four catches for 38 yards.

Mullens went 18 of 26 for 200 yards with two interceptions and one touchdown; Beathard was 14 of 19 for 138 yards.

The 49ers outgained the Eagles 417-267.

--Field Level Media