DENVER -- Michael McKenry's home run gave the Colorado Rockies a much-needed win and provided him with both a personal milestone and a welcome feeling of redemption.

His two-run shot with two outs in the 11th inning on Wednesday lifted the Rockies to a 7-5 victory over the Seattle Mariners.

McKenry's fourth homer of the season came against Mayckol Guaipe (0-3) and was his first career walk-off hit.

Manager Walt Weiss said McKenry was "beating himself up" over a ninth-inning at-bat on Monday night after he struck out with runners on first and third with one out and the Rockies trailing 8-7 in a game they ended up losing.

McKenry was picked off first base Tuesday night, frozen by left-hander Vidal Nuno's move and never even breaking toward second. And McKenry has been dealing with a painful cyst behind his right knee.

"Sometimes life's trying to bring you down," McKenry said. "You've just got to stay on the grind, keep your head up and keep going. Sometimes it's tough, but you just got to keep running forward."

Yohan Flande (2-1), the eighth Colorado pitcher, came away with his second major league win in the four-hour, six-minute marathon. He is still scheduled to start Saturday at Washington after throwing 16 pitches in the 11th.

McKenry's homer gave the Rockies just their third win in 10 games and some satisfaction after suffering three walk-off losses during a recent 2-5 road trip to Chicago and St. Louis.

In addition to McKenry's homer, right fielder Carlos Gonzalez belted a three-run shot in the sixth off Mariners starter Taijuan Walker that tied the score at 3.

Rockies reliever Rafael Betancourt came on in the 10th with one out and runners on second and third and struck out shortstop Ketel Marte and got third baseman Kyle Seager to fly out.

Paulsen, who had three hits, including a single ahead of McKenry's winning blast, doubled home a run in the ninth after Mariners reliever Fernando Rodney came on with one out and walked second baseman DJ LeMahieu. Paulsen scored on left fielder Kyle Parker's single that tied it at 5 and tagged Rodney with his sixth blown save in 22 chances.

"This guy has been up four out of five days," Mariners manager Lloyd McClendon said of Rodney. "He has a right to get tired, too. I protect the young kids, but four out of five days is tough. This was a tough situation in a tough ballpark. The walk hurt."

McClendon said he planned to use Carson Smith, who has 10 saves, for just one batter in the eighth -- he got third baseman Nolan Arenado to ground into an inning-ending double play -- and that reliever Tom Wilhelmsen was unavailable.

Rockies starter Chris Rusin, who worked five innings, gave up five hits in the fourth when the Mariners batted around but limited the damage to three runs after he retired Seager on a grounder to leave the bases loaded. In all, Rusin stranded eight runners and gave the Rockies a chance to win.

So did Gonzalez with his two-out homer in the sixth off Walker. To that point, Walker, who worked 7 1/3 innings, had allowed two hits.

Weiss said after Gonzalez hit his 22nd homer of the season, he turned to bench coach Tom Runnells and said, "These guys are killing us 3-3. That's what it felt like. Walker was in complete control of the game, and he was pretty filthy."

Mariners left fielder Franklin Gutierrez hit a two-run homer in the seventh that sent the Mariners ahead 5-3. It was Gutierrez's fourth homer and came against reliever John Axford.

Axford, who was taken out of the closer's role last week, has been scored upon in five of his past seven outings, going 2-3 with four blown saves and a 13.50 ERA (6 2/3 innings, 10 earned runs) during that span.

But the Rockies atoned for Axford's stumble by rallying against Rodney. And then they left for what looms as a difficult road trip -- three games at Washington and four at New York against the Mets -- with the wind at their backs after McKenry's heroics against Guaipe on a 2-2 slider.

"He threw me a nasty one the pitch before and I fouled it off," McKenry said. "Luckily. that one kind of hung up there for me.

"I knew it (was gone) right when I hit it, which is even more gratifying."

NOTES: Mariners RF Nelson Cruz, who extended his hitting streak to 16 games, is the fifth player in major league history to homer in at least five consecutive games twice in the same season. The others are Hall of Famer Harmon Killebrew (1970 Twins), Hall of Famer Frank Thomas (1994 White Sox), Barry Bonds (2001 Giants) and Chase Utley (2008 Phillies). Cruz did not homer Wednesday. ... Mariners LHP Vidal Nuno, who made a spot start Tuesday, will start again when his turn in the rotation comes up Monday against Baltimore. ... LF Kyle Parker jumped into the stands to catch a foul ball hit by SS Ketel Marte in the sixth. ... Mariners RHP Taijuan Walker had gone hitless in six at-bats with four strikeouts and a sacrifice in seven career plate appearances before producing a run-scoring ground-rule double in the fourth. The ball went over first base and hit off the padding down the right field line and was picked up by the Rockies security attendant stationed nearby. He realized his error and quickly tossed the ball aside.