Eric Hosmer capped a four-run first inning by hitting a three-run homer, and the San Diego Padres held on for a 5-4 victory over the New York Yankees on Tuesday night at Yankee Stadium.

The Padres evened the series by taking a four-run lead four batters in after New York third baseman DJ LeMahieu misplayed a grounder by leadoff man Greg Garcia for an error.

Franmil Reyes singled, and San Diego grabbed a 1-0 lead when Manny Machado scored Garcia by hitting a bloop single into left field. Two pitches later, Hosmer hit his ninth homer, hammering Masahiro Tanaka's 1-0 sinker 431 feet over the center field fence.

The Padres did little else off Tanaka (3-4) but added a run by stringing together three hits in the sixth and scoring on a bunt single by Garcia.

The early offense against Tanaka was barely enough for San Diego to win for the sixth time in eight games.

Gary Sanchez homered for the Yankees, who lost for only the third time in their past 15 games. LeMahieu hit a two-run, bases-loaded single, and Aaron Hicks hit an RBI grounder in the seventh off Craig Stammen, the fourth San Diego reliever of the inning.

San Diego left-hander Eric Lauer (4-4) made the early offense hold up, allowing one run on four hits in 5 1/3 innings. He struck out four, walked none and threw 83 pitches.

Lauer served up Sanchez's 17th homer with one out in the fourth on a 1-2 fastball that landed on the netting over Monument Park in center field.

After getting the first out of the sixth, Lauer yielded consecutive singles to Luke Voit and Aaron Hicks.

Matt Wisler followed Lauer and finished the inning by striking out Sanchez with a nasty slider and retiring Gleyber Torres on a fly ball.

The Padres used Brad Wieck, Phil Maton, Robbie Erlin and Stammen to barely keep the lead in the seventh. Erlin allowed a single to Brett Gardner that loaded the bases. Stammen let in two runs but ended the inning by retiring Sanchez on a flyout.

Stammen pitched a perfect eighth, and Kirby Yates pitched a scoreless ninth for his 21st save. Yates remained perfect in save opportunities when he induced a double play by LeMahieu, who was originally called safe before the ruling was changed on replay.

Tanaka allowed five runs (four earned) and a season-high nine hits in six innings. He struck out seven and walked two.

--Field Level Media