Abreu slammed a 3-0 pitch from right-hander Ryan Tepera (1-1) a booming 430 feet into the restaurant level above the left-center field fence to help Chicago end a two-game slide.
Nate Jones (1-0) got four outs and fellow right-hander Joakim Soria struck out two in a perfect ninth for his second save as the White Sox halted Toronto's four-game winning streak.
Matt Davidson also homered for Chicago, which leads the majors with 14.
Toronto right-hander Aaron Sanchez allowed three runs and five hits in six innings, striking out seven and walking two. White Sox right-hander Carson Fulmer gave up three runs, five hits and one walk while striking out five in five innings.
The White Sox pushed across two runs in the fifth with help from a review to take a 3-1 lead.
The bases were loaded with one out when Yoan Moncada sent a deep blast to the wall in left. Toronto's Curtis Granderson leaped and the ball appear to either deflect off the wall or off Granderson's glove.
Granderson fell to the ground and the ball followed and landed in his glove for what was ruled to be the second out.
However, on review, the ball was ruled to hit the top of the fence behind Granderson's glove before he made the grab, and the play was ruled to be a run-scoring single for Moncada. Sanchez hit the following batter, Adam Engel, to force in another run and make it 3-1.
The Blue Jays tied the score in the bottom of the sixth on two run-scoring singles. Steve Pearce delivered a pinch hit to left for the first run and Kendrys Morales tied it with a liner to center.
Chicago opened the scoring in the second when Davidson lined a 3-1 pitch over the wall in left for his fourth homer of the campaign.
Russell Martin's grounder pushed across a run in the fourth as Toronto tied the score at 1.
--Field Level Media
Chi. White Sox | Toronto | |
Carson Fulmer | Player | Aaron Sanchez |
No Decision | W/L | No Decision |
5.0 | IP | 6.0 |
5 | Strikeouts | 7 |
4 | Hits | 6 |
3.60 | ERA | 4.50 |
Chi. White Sox | Toronto | |
Yolmer Sanchez | Player | Curtis Granderson |
2 | Hits | 2 |
0 | RBI | 0 |
0 | HR | 0 |
3 | TB | 3 |
.500 | Avg | 1.000 |
Team | Hits | HR | TB | Avg | LOB | K | RBI | BB | SB | Errors |
Chi. White Sox | 8 | 2 | 15 | .258 | 12 | 11 | 4 | 2 | 0 | 1 |
Toronto | 6 | 0 | 8 | .176 | 13 | 10 | 3 | 1 | 0 | 0 |