MIAMI -- Giancarlo Stanton was realistic after his franchise-record streak of home runs in six consecutive games was snapped.

"I ain't going to hit a homer in 45 games straight," Stanton said.

Stanton, who leads the majors with 44 homers, still went 2-for-4 on Wednesday as his Miami Marlins defeated the San Francisco Giants 8-1 at Marlins Park.

Marlins manager Don Mattingly, who homered in eight consecutive games in 1987, holds the major league record -- along with Ken Griffey Jr. and Dale Long.

"It would've been cool to mess with (Mattingly) a bit if I could've (broken his record)," Stanton said. "But I felt good. We won."

Jose Urena (11-5), who leads the Marlins in wins, allowed just one run, unearned, in five innings, improving his ERA to 3.61. Urena got defensive help in the third inning from speedy second baseman Dee Gordon, who fielded a one-hop grounder from Nick Hundley and beat the catcher to the first-base bag.

Despite not going deep on Wednesday, Stanton has slugged 11 homers in his past 13 games and 23 in 36 games. He is on pace to hit 60 homers this year, a milestone reached by only five players in major league history.

"He's going to hit 60," Urena said of Stanton. "I hope he hits 61 and 62.

"For the fans, everyone is waiting for him to hit a home run. That's what we (as players) are waiting for, too."

With Stanton held in check, little-used first baseman Tomas Telis, making just his ninth start of the year, went 2-for-4 with a season-high three RBIs.

Telis helped the Marlins (58-61) take two of three games from the Giants (48-74). The Marlins have now won six of their past eight series.

Giants starter Matt Cain (3-10), who lasted just four innings, allowed five runs, two earned. He is winless in his past 13 starts, going a career-worst 0-9 in that span. He hasn't won a game in more than three months (May 15).

All three of Cain's unearned runs occurred in the first inning, when Miami scored four times.

The Giants were hurt by catcher's interference charged against Hundley and a fielding error on shortstop Brandon Crawford. Miami's biggest hit of the inning was a two-run, opposite-field double by Telis.

Stanton got hit by a pitch in the second inning when Cain tried to tie him up inside on a full-count, 91-mph fastball.

"He's been pretty comfortable (at the plate)," Cain said of Stanton. "I tried to keep him off balance.

"That's the biggest thing with Stanton -- if he gets extended, he has a good chance of putting good wood on the ball. ... It got away from me. It's 3-2. I tried to be on the inner-third. I tried to keep the barrel off (the ball), and I missed way up."

San Francisco, taking advantage of a two-out fielding error by Telis, scored a run in the third, cutting Miami's lead to 4-1.

But the Marlins went ahead 5-1 in the bottom of the third when Derek Dietrich smoked a triple to the gap in right-center and scored on a single by Telis. It was Dietrich's fifth triple of the year, tying his career best.

Giants reliever Albert Suarez walked two batters in the fifth, and that led to a pair of Marlins runs on RBI singles by Mike Aviles and pinch hitter Ichiro Suzuki. It was Suzuki's 20th pinch hit of the season, one short of the Marlins record set by Ross Gload in 2009.

Miami got its final run in the seventh when pinch-hitter Miguel Rojas' single drove in Aviles.

Giants manager Bruce Bochy, who has started 16 different outfielders and eight third basemen in an injury-plagued season, didn't take solace in breaking Stanton's streak.

"I'd rather he hit a home run," Bochy said, "and we win the game."

NOTES: Marlins RHP Jose Urena has 11 wins following a team loss, leading the majors in that category. ... Marlins RF Giancarlo Stanton on Tuesday finished a stretch of 35 games in which he hit 23 homers. Only three other hitters in major league history have matched or exceeded that stretch in one season: Sammy Sosa (25 in 1998), Barry Bonds (24, 2001) and Mark McGwire (23, 1999). ... Giants 2B Joe Panik was placed on the seven-day concussion disabled list retroactive to Monday. He was hit on the head during a home-plate collision on Sunday at the Washington Nationals. ... Giants RHP Johnny Cueto (blisters) will throw a bullpen session on Friday. ... INF Miguel Gomez (right knee) will start a rehab assignment on Thursday at Class A San Jose and could be activated by the Giants by Saturday. ... Miami opens a three-game series at the New York Mets on Friday. ... The Giants return home to open a four-game series against the Philadelphia Phillies on Thursday.