TORONTO -- First baseman Justin Smoak and second baseman Devon Travis each hit two-run homers and the Toronto Blue Jays defeated the Baltimore Orioles 4-2 on Wednesday night.

Designated hitter Jimmy Paredes hit a two-run homer for the Orioles.

Blue Jays rookie right-hander Aaron Sanchez (1-2) held the Orioles to two runs despite allowing seven walks and two hits that included a home run in 5 1/3 innings to pick up his first win of the season.

Orioles right-hander Ubaldo Jimenez (1-1) gave up four runs and six hits that included two home runs and three walks to take his first loss this year.

Blue Jays right-hander Miguel Castro entered the game with two outs in the eighth to pick up his third save of the season.

The victory assured the Blue Jays (8-7) their second series win over the Orioles (7-8) this season. They have won four of the first five games played between the American League East rivals this season.

The Orioles have lost three in a row overall and the Blue Jays have won two straight games.

Sanchez was removed for right-hander Roberto Osuna with one out in the sixth after he allowed his seventh walk of the game and second of the inning. Osuna surrendered a single to Orioles third baseman Manny Machado to load the bases before retiring second baseman Ryan Flaherty on a popout to short and striking out catcher Caleb Joseph to end the threat.

Machado led off the ninth with a double against Castro, who then walked Flaherty. Joseph took a called third strike before pinch-hitter Delmon Young bounced into a double play on a grounder to shortstop.

Sanchez struggled with his control early and the Orioles made him pay.

Joseph drew the fourth walk from Sanchez to lead off the third and scored on the first home run of the season by Paredes, who hit a drive to left.

Sanchez walked two batters in the first but escaped the inning when Orioles center fielder Adam Jones lined into a double play. Another walk was erased in the second when Flaherty grounded into a double play.

Jimenez gave up his first walk of the game to designated hitter Edwin Encarnacion to lead off the fourth. It proved damaging when Smoak sliced his first home run of the season to left to tie the score at 2.

Toronto shortstop Jose Reyes led off the fifth with a single and Travis brought him home with a blast to center for his fourth homer of the season to give the Blue Jays a 4-2 lead.

NOTES: RF Jose Bautista (right shoulder strain) will miss a few days and Blue Jays manager John Gibbons said a trip to the disabled list is possible. The shoulder bothered Bautista for a week before he aggravated it Tuesday during a throw to first base on a single by OF Delmon Young in the eighth inning of the 13-6 win over the Orioles. ... LF Michael Saunders (left knee surgery) could return to the Blue Jays this weekend. ... 2B Devon Travis (bruised left rib) returned to Toronto's lineup on Wednesday after missing one game, enabling INF Ryan Goins to play left field and OF Kevin Pillar to move to right. ... The 13 runs on Tuesday are the most Baltimore has allowed since Aug. 27, 2013, at Boston. ... Baltimore will start RHP Chris Tillman (2-1, 5.52 ERA) against Toronto RHP Drew Hutchison (1-0, 7.20 ERA) in Thursday's finale of the three-game series.